Testosterone is the main male sex hormone, which is synthesized mainly in the testes and determines the development of masculine characteristics, such as facial hair and developed skeletal muscles. In case of insufficient production of endogenous testosterone due to a disease, or age-related changes, hormonal replacement therapy can be carried out. In case of hypogonadism in men, testosterone replacement therapy can lead to an increase in skeletal muscle mass, increase in strength of bone tissue and enhance protein synthesis. Similar results can be achieved in the case of the use of synthetic testosterone in healthy young men. This explains the wide popularity of androgenic anabolic steroids among athletes.
Unfortunately, in addition to positive effects, steroids have negative side effects, of which we wrote a separate large review, and with which we recommend to familiarize everyone who at least thinks about the use of pharmacological drugs. Do not take steroids! Hormone replacement therapy is allowed only under the supervision of a doctor. But, unfortunately, these warnings do not stop everyone. And since the effectiveness of the application of androgenic anabolic steroids depends on dosages, the chance of seriously harming one’s health increases with each “course” in geometric progression.
But athletes are stubborn people, and since the use of steroids is one of the important conditions for victory in many sports, athletes who want to be winners are forced to use them. Those who do not already think about whether to take steroids or not, but only choose which drug to use, we recommend paying attention to the Oxandroxyl. Why? Because it is the only steroid approved by the US FDA.
History of Anavar
In 1960, the androgenic anabolic steroid Oxandrolone was synthesized, which was marketed by G.D. Searle & Co under the brand name Anavar. The drug successfully survived until 1989. It was widely used in medicine because it had many positive effects and demonstrated its safety when applied in therapeutic doses under the supervision of a physician. But due to the fact that in the late 1980s and early 1990s the FDA pressured the market for steroids, G.D. Searle & Co simply stopped producing Anavar. And until the mid-1990s, Oxandrolone was a deficit. The situation changed in 1995, when Bio-Technology General CORP (BTG) released a new line of Oxandrolone under the Oxandrin brand.
As a result, BTG became monopolists, which led to higher prices for Oxandrolone, and it became one of the most expensive steroids on the market. And this is all that the FDA has done with its bans! Oxandrolone has simply become less accessible. Have dishonest athletes stopped doping? Most likely, they just switched to cheaper drugs. And Oxandrolone, although it has all the side effects characteristic of steroids, is one of the safest synthetic hormonal drugs. The funny thing is that although Oxandrolone has not been released under the brand name “Anavar” since 1989, this trademark has become its second name. And fakes under such a trade brand are not uncommon, while the FDA today recommends it to use for certain diseases.
Oxandroxyl is a synthetic, non-aromatizable testosterone derivative, with a virilization effect of 5% to testosterone and a lower hepatotoxicity. Refers to the 17α-alkylated group of androgenic anabolic steroids. It is taken in oral form. It has a pronounced anabolic with a low androgenic activity. It is the only steroid in which the carbon atom in the phenanthrene nucleus is replaced by oxygen, in addition, Oxandroxyl is purified by the kidneys, and not by the liver, which ensures its low hepatotoxicity, which allows the FDA to recommend the use of an Oxandroxyl at doses greater than 20 mg/day.
Oxandroxyl is used to preserve or restore muscle mass in various clinical cases, as well as to promote the occurrence of a favorable outcome in the treatment of certain diseases. It is successfully used in the treatment of children with Turner’s syndrome, are given to HIV-infected, with burns, and other diseases. It promotes the hypertrophy of skeletal muscles and the growth of strength indicators, promotes the synthesis of protein in skeletal muscles, influencing the transport of amino acids in the cell, facilitates the utilization of visceral fat, inhibits the destructive effect of cortisol, promotes the synthesis of collagen, possibly initiates muscle cell hyperplasia and stimulates the sensitivity of androgen receptors.
It should be noted that all these results could be achieved with the use of Oxandroxyl at dosages of 0.1 mg/kg of body weight per day, 15 mg/day, 20 mg/day, and such dosages in these studies were used for several months. Athletes, on the contrary, often take overpriced dosages, reaching almost 100 mg/day for 6-8 weeks, which, although it can give a greater result in the growth of muscle mass and strength, but also increases the risk of side effects. And in this sense, although it is highly recommended not to take steroids without recommendations and doctor’s supervision, it is better to take them at such dosages that have been clinically tested.
Conclusion: Oxandroxyl is a trademark of the androgenic anabolic steroid Oxandrolone. Oxandrolone is a pronounced anabolic, which practically does not aromatize, but affects the synthesis of skeletal muscle protein and athlete’s strengths, both due to hypertrophy and, possibly, hyperplasia of muscle cells, and by improving neuromuscular communication. But it should be remembered that steroids have undesirable side effects, so they should be used only on the advice of a doctor.